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Abstract We explore an interacting dark matter (IDM) model that allows for a fraction of dark matter (DM) to undergo velocity-independent scattering with baryons. In this scenario, structure on small scales is suppressed relative to the cold DM scenario. Using the effective field theory of large-scale structure, we perform the first systematic analysis of BOSS full-shape galaxy clustering data for the IDM scenario, and we find that this model ameliorates theS₈tension between large-scale structure and Planck data. Adding theS₈prior from the Dark Energy Survey (DES) to our analysis further leads to a mild ∼3σpreference for a nonvanishing DM–baryon scattering cross section, assuming ∼10% of DM is interacting and has a particle mass of 1 MeV. This result produces a modest ∼20% suppression of the linear power atk≲ 1hMpc⁻¹, consistent with other small-scale structure observations. Similar scale-dependent power suppression was previously shown to have the potential to resolveS₈tension between cosmological data sets. The validity of the specific IDM model explored here will be critically tested with upcoming galaxy surveys at the interaction level needed to alleviate theS₈tension. 

Abstract We use new cosmic microwave background (CMB) primary temperature and polarization anisotropy measurements from the Atacama Cosmology Telescope (ACT) Data Release 6 (DR6) to test foundational assumptions of the standard cosmological model, ΛCDM, and set constraints on extensions to it. We derive constraints from the ACT DR6 power spectra alone, as well as in combination with legacy data from thePlanckmission. To break geometric degeneracies, we include ACT andPlanckCMB lensing data and baryon acoustic oscillation data from DESI Year-1. To test the dependence of our results on non-ACT data, we also explore combinations replacingPlanckwithWMAPand DESI with BOSS, and further add supernovae measurements from Pantheon+ for models that affect the late-time expansion history. We verify the near-scale-invariance (running of the spectral indexdn_s/dlnk= 0.0062 ± 0.0052) and adiabaticity of the primordial perturbations. Neutrino properties are consistent with Standard Model predictions: we find no evidence for new light, relativistic species that are free-streaming (N_eff= 2.86 ± 0.13, which combined with astrophysical measurements of primordial helium and deuterium abundances becomesN_eff= 2.89 ± 0.11), for non-zero neutrino masses (∑m_ν< 0.089 eV at 95% CL), or for neutrino self-interactions. We also find no evidence for self-interacting dark radiation (N_idr< 0.134), or for early-universe variation of fundamental constants, including the fine-structure constant (α_EM/α_EM,0= 1.0043 ± 0.0017) and the electron mass (m_e/m_e,0= 1.0063 ± 0.0056). Our data are consistent with standard big bang nucleosynthesis (we findY_p= 0.2312 ± 0.0092), theCOBE/FIRAS-inferred CMB temperature (we findT_CMB= 2.698 ± 0.016 K), a dark matter component that is collisionless and with only a small fraction allowed as axion-like particles, a cosmological constant (w= -0.986 ± 0.025), and the late-time growth rate predicted by general relativity (γ= 0.663 ± 0.052). We find no statistically significant preference for a departure from the baseline ΛCDM model. In fits to models invoking early dark energy, primordial magnetic fields, or an arbitrary modified recombination history, we findH₀= 69.9^+0.8_-1.5, 69.1 ± 0.5, or 69.6 ± 1.0 km/s/Mpc, respectively; using BOSS instead of DESI BAO data reduces the central values of these constraints by 1–1.5 km/s/Mpc while only slightly increasing the error bars. In general, models introduced to increase the Hubble constant or to decrease the amplitude of density fluctuations inferred from the primary CMB are not favored over ΛCDM by our data. 

How knotted proteins fold has remained controversial since the identification of deeply knotted proteins nearly two decades ago. Both computational and experimental approaches have been used to investigate protein knot formation. Motivated by the computer simulations of Bölinger et al. [Bölinger D, et al. (2010)PLoS Comput Biol6:e1000731] for the folding of the $6_1$-knotted α-haloacid dehalogenase (DehI) protein, we introduce a topological description of knot folding that could describe pathways for the formation of all currently known protein knot types and predicts knot types that might be identified in the future. We analyze fingerprint data from crystal structures of protein knots as evidence that particular protein knots may fold according to specific pathways from our theory. Our results confirm Taylor’s twisted hairpin theory of knot folding for the $3_1$-knotted proteins and the $4_1$-knotted ketol-acid reductoisomerases and present alternative folding mechanisms for the $4_1$-knotted phytochromes and the $5_2$- and $6_1$-knotted proteins.